The Correlation Between Cancer And Prostate Cancer

The finding led to the belief that the solution lied in the saturation, where the maximal growth of the prostate cancer was achieved at a low level of testosterone. This model was produced by Fowler and Whitmore, who concluded â€Å"normal endogenous testosterone levels may be sufficient to cause near maximal stimulation of prostatic tumors.† There final conclusion was that â€Å"there is not today—nor has there ever been—a scientific basis for the contention that a higher T concentration causes pCA growth, acutely or long-term.† This was a pivotal discovery because many other research labs began to do work on this same theory. Even though the other labs were doing the same research, they all came to similar results to of Huggins and Hodges, and†¦show more content†¦Nevertheless, like humans, the animal samples showed that androgens alone are sufficient to the induction of prostate carcinogenesis. In this study, the mean age of the patients who w ere sample was about 63 years of age and the median time that it took to diagnose those patients was almost three years. Testosterone, in this study, was moderately correlated with SHBG, but weakly correlated with estradilol. This is when Black et al used the ratio of estradilol: testosterone because they found an decrease between the ratio and the risk of acquiring prostate cancer. The overall conclusion was acquired from the data was found what that in men 70 years of age or greater a higher ratio of estradilol: testosterone was strongly associated with a reduced risk, and the control of the ratio would reduce the risk of acquiring prostate cancer. The risk of having prostate cancer was observed as higher with a ratio of 2:16ÃŽ ±-hydroxyestrone. Even though it was found that there is low risk of getting prostate cancer, they did consider the balance is important in how aggressive the prostate cancer is, or may become. [4] A study that was done by Chen et al observed that androgens like testosterone were vital in the growth and maintenance of prostate cancer. Subsequently, they gave large doses of these androgens to rodents. The other observations included the incidence of prostate cancer was very low in men who were castrated, and androgens stimulate the in vitro